Clozapine Clinical and Research Database

Data from 2013 of a cohort of people prescribed with clozapine

What is the Database?

  • Purpose

    A database containing pseudo-anonymised data from regular clinical interviews held at the local NHS trust (Cambridgeshire and Peterborough NHS Foundation Trust).

    Started in 2013 and continues gathering information, with over 230 individuals and over 4,000 face to face appointments.

  • Ethically approved

    The database has gone three cycles of ethical approvals (13/EE/0121; 18/EE/0239; 24/EE.0217)

    It is open to other researchers who are willing to collaborate.

  • Open to collaborations

    If you have an idea that you would like to explore, please contact us. The proposal will be evaluated by the psychosis centre team and get back to you as soon as possible

  • Published research

    The Database has provided data for several publications, including BJPsych, Psychological Medicine, Spanish Journal of Psychiatry, JCPsychopharmacology, Schizophrenia Research and others

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What does it contain?

It contains routine clinical information, completely anynomised (no DoB, no address, no NHS numbers, etc..).

Typically, patients are seen between 1 and 6 times per year, depending on the clinical situation.

A systematic and structured interview is conducted, with a range of clinical, sociodemographic and scales collected.

The database has evolved over the years, from basically collecting diagnosis, treatment and GAF and CGI-S, to incorporating new scales and wider information. I

t is a relatively complex but organised matrix, allowing both cross-sectional and longitudinal studies.

  • Age, gender,

  • Mental health and non-mental health diagnosis,

    Prescribed mental health medications with doses

    Prescribed medications by GP (less reliable information)

  • Birth weight and hand dominance.

    Data and age at first episode psychosis, type of episode, triggers (cannabis).

    Admissions (first and last, and legal status, mildly reliable information)

    Medication pre-clozapine (mildly relaible).

    Date first treatment with clozapine

    Last plasma levels.

    Peak dose of clozapine, current dose of clozapine.

    Augmentation strategies (reason and year, mildly reliable).

  • Smoking habit - cigarettes/ day

    Alcohol use - unit of alcohol per day

    Self reported illegal drug use.

  • Age of parents, siblings and children.

    Family history of mental health

    Family history of type 2 diabetes

  • From 2013, on each assessment GAF and CGI-Schizophrenia

    From 2016, OCI-R and Wellbeing Scale (SWEWMS), annually.

    from 2018, BNSS, Calgary, and PANSS positive, every other year.

    Ad hoc: Trauma questionnaires and SDS

  • number of hours sleep per day (proxy of sedation)

    Level of hyper salivation and constipation (absent, minor, major, on treatment)

    KARDIA evaluation (from 2022, ad hoc)

    Last appointment with GP.

    Information regarding metabolic syndrome (categorical)